Racial/Ethnic Disparities on the Risk of Second Malignant Neoplasm Among Hodgkin Lymphoma Survivors

Frontiers in Oncology

Jianghua He¹  Duo Cai²  Qing Xiao²  Simin Liang²  Xinyu Yan²  Li Wang²  Lanxiang Liu²  Han Xiao²  Qiao Zhou²  Jianxiang Chi³ 

[1] Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, KS, United States;Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China;The Center for the Study of Hematological Malignancies, Karaiskakio Foundation, Nicosia, Cyprus;

关键词: Hodgkin lymphoma;    second malignant neoplasm;    SEER database;    racial/ethnic disparities;    cancer surveillance;   

DOI  :  10.3389/fonc.2021.790891

来源: DOAJ

【 摘 要 】

BackgroundHodgkin lymphoma survivors are at risk for second malignant neoplasm (SMN). How race/ethnicity affects the risk remains unclear.MethodsThis retrospective cohort study included 22,415 patients diagnosed with primary Hodgkin lymphoma from January 1992 to December 2015 in 13 Surveillance, Epidemiology, and End Results-based registries and divided patients into four groups: non-Hispanic whites, non-Hispanic blacks, Hispanics, and Asian/others. Taking non-Hispanic whites as a reference, both the proportional subdistribution hazard (PSH) and the cause-specific hazard (CSH) methods were used to calculate the SMN hazard ratio for other racial/ethnic groups with and without considering the competing mortality risk.Results1,778 patients developed SMN with a median follow-up of 11.63 years. In the adjusted PSH model, Hispanic, Asian/others, and non-Hispanic black patients had 26% (PSH, 0.74; 95% CI, 0.63–0.87), 20% (PSH, 0.80; 95% CI, 0.64–1.01), and 12% (PSH, 0.88; 95% CI, 0.75–1.03) decreased overall SMN hazard, respectively. Moreover, the PSH method revealed the racial/ethnic difference in the SMN risk in the skin, the respiratory system, and the endocrine system. These hazards were slightly higher and different with the use of the CSH approach. In addition to the aforementioned overall SMN and subtypes, adjusted CSH analysis also revealed the racial/ethnic disparities in the risk of subsequent female breast cancer, digestive cancer, and non-Hodgkin lymphoma.ConclusionsThe subtype and SMN risk among Hodgkin lymphoma survivors varied by race/ethnicity. The use of CSH and PSH provides a dynamic view of racial/ethnic effects on SMN risk in Hodgkin lymphoma survivors.

【 授权许可】

Unknown