Secreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker

Biomolecules

Mayumi Yoshioka¹  Jonny St-Amand¹  Abdelaziz Ghanemi¹ 

[1] Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Québec, QC G1V 4G2, Canada;

关键词: secreted protein acidic and rich in cysteine;    expression;    physiology;    pathology;    biomarker;   

DOI  :  10.3390/biom11111689

来源: DOAJ

【 摘 要 】

Secreted protein acidic and rich in cysteine (SPARC) is expressed in diverse tissues and plays roles in various biological functions and processes. Increased serum levels of SPARC or its gene overexpression have been reported following numerous physiological and pathological changes including injuries, exercise, regeneration, obesity, cancer, and inflammation. Such expression pattern interrelation between these biological changes and the SPARC expression/secretion points to it as a biomarker. This property could lead to a variety of potential applications ranging from mechanistic studies and animal model validation to the clinical and therapeutic evaluation of both disease prognosis and pharmacological agents.

【 授权许可】

Unknown