Development, Validation and Application of a Targeted LC-MS Method for Quantification of Microcystins and Nodularin: Towards a Better Characterization of Drinking Water

Water

Annick Wilmotte¹  Mirjana Andjelkovic²  Wannes Hugo R. Van Hassel³  Bart Huybrechts³  Julien Masquelier³ 

[1] InBios-Centre for Protein Engineering, Departement of Life Sciences, Faculty of Sciences, University of Liège, Allée du Six Août 11, 4000 Liège, Belgium;Risk and -Health Impact Assessment, Sciensano, Rue Juliette Wytsmanstraat 14, 1050 Brussels, Belgium;Unit Toxins, Organic Contaminants and Additives, Sciensano, Rue Juliette Wytsmanstraat 14, 1050 Brussels, Belgium;

关键词: water;    microcystin;    liquid chromatography;    mass spectrometry;    method validation;    matrix effect;   

DOI  :  10.3390/w14081195

来源: DOAJ

【 摘 要 】

Cyanotoxins can be produced in surface waters by cyanobacterial blooms, mostly during summer and early autumn. Intoxications would result from consumption of water contaminated with the potent hepatotoxins, microcystins and nodularin. Therefore, the WHO has set a guideline value for drinking water quality concerning one congener of microcystin. Consequently, the design of a validated, public reference method to detect and quantify the hepatotoxins in drinking water is necessary. During this study, a method was developed to quantify cyanotoxins (eight microcystin congeners and nodularin) in water using liquid chromatography coupled with tandem mass spectrometry. Additionally, bottled and tap water samples were tested for the presence of cyanotoxins. No cyanotoxins were detected in any of the collected water samples. However, quality controls and the results of a proficiency test show the validity of the method.

【 授权许可】

Unknown