Swine coronaviruses (SCoVs) and their emerging threats to swine population, inter-species transmission, exploring the susceptibility of pigs for SARS-CoV-2 and zoonotic concerns

Veterinary Quarterly

Wanpen Chaicumpa¹  Manish Dhawan²  Talha Bin Emran³  Megha Katare Pandey⁴  Ruchi Tiwari⁵  Monalisa Sahoo⁶  Murali Dinesh⁶  Kuldeep Dhama⁶  Jigarji C. Thakor⁶  Diptimayee Sahoo⁶  Suresh Bindu⁷  Rajendran Manikandan⁷ 

[1] Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;Department of Microbiology, Punjab Agricultural University, Ludhiana, India;Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh;Department of Translational Medicine Center, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India;Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura, India;Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India;Immunology Section, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India;

关键词: Pig;    porcine;    Coronaviruses;    SARS-CoV-2;    zoonosis;   

DOI  :  10.1080/01652176.2022.2079756

来源: DOAJ

【 摘 要 】

Swine coronaviruses (SCoVs) are one of the most devastating pathogens affecting the livelihoods of farmers and swine industry across the world. These include transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine respiratory coronavirus (PRCV), porcine hemagglutinating encephalomyelitis virus (PHEV), swine acute diarrhea syndrome coronavirus (SADS-CoV), and porcine delta coronavirus (PDCoV). Coronaviruses infect a wide variety of animal species and humans because these are having single stranded-RNA that accounts for high mutation rates and thus could break the species barrier. The gastrointestinal, cardiovascular, and nervous systems are the primary organ systems affected by SCoVs. Infection is very common in piglets compared to adult swine causing high mortality in the former. Bat is implicated to be the origin of all CoVs affecting animals and humans. Since pig is the only domestic animal in which CoVs cause a wide range of diseases; new coronaviruses with high zoonotic potential could likely emerge in the future as observed in the past. The recently emerged severe acute respiratory syndrome coronavirus virus-2 (SARS-CoV-2), causing COVID-19 pandemic in humans, has been implicated to have animal origin, also reported from few animal species, though its zoonotic concerns are still under investigation. This review discusses SCoVs and their epidemiology, virology, evolution, pathology, wildlife reservoirs, interspecies transmission, spill-over events and highlighting their emerging threats to swine population. The role of pigs amid ongoing SARS-CoV-2 pandemic will also be discussed. A thorough investigation should be conducted to rule out zoonotic potential of SCoVs and to design appropriate strategies for their prevention and control.

【 授权许可】

Unknown