Progress on the Stereoselective Synthesis of Chiral Molecules Based on Metal-Catalyzed Dynamic Kinetic Resolution of Alcohols with Lipases

Symmetry

Raffaella Ferraccioli¹ 

[1] Istituto di Scienze e Tecnologie Chimiche “Giulio Natta” (SCITEC), CNR, Via Mancinelli 7, 20131 Milan, Italy;

关键词: alcohol;    ester;    kinetic resolution;    racemization;    dynamic kinetic resolution;    lipase;   

DOI  :  10.3390/sym13091744

来源: DOAJ

【 摘 要 】

Metal/lipase-combo catalyzed dynamic kinetic resolution (DKR) of racemic chiral alcohols is a general and practical process to obtain the corresponding enantiopure esters R with quantitative conversion. The use of known Ru-catalysts as well as newly developed homogeneous and heterogeneous metal catalysts (Fe, V) contributed to make the DKR process more sustainable and to expand the substrate scope of the reaction. In addition to classical substrates, challenging allylic alcohols, tertiary alcohols, C1-and C2-symmetric biaryl diols turned out to be competent substrates. Synthetic utility further emerged from the integration of this methodology into cascade reactions leading to linear/cyclic chiral molecules with high ee through the formation of multiple bonds, in a one-pot procedure.

【 授权许可】

Unknown