The prognostic performance of the log odds of positive lymph nodes in patients with esophageal squamous cell carcinoma: A population study of the US SEER database and a Chinese single‐institution cohort

Cancer Medicine

Lei Gong¹  Ran Jia¹  Peng Tang¹  Hongdian Zhang¹  Kai Zhu¹  Wanyi Xiao¹  Peng Ren¹  Yueyang Yang¹  Zhentao Yu² 

[1] Department of Esophageal Cancer Tianjin Medical University Cancer Institute and Hospital Key Laboratory of Cancer Prevention and Therapy of Tianjin Tianjin's Clinical Research Center for Cancer National Clinical Research Center of Cancer Tianjin China;Department of Thoracic Surgery National Cancer Center National Clinical Research Center for Cancer Cancer Hospital & Shenzhen Hospital Chinese Academy of Medical Sciences and PeKing Union Medical College Shenzhen China;

关键词: a Chinese single‐institution cohort;    esophageal squamous cell carcinoma;    log odds of positive lymph nodes;    prognosis;    SEER database;   

DOI  :  10.1002/cam4.4120

来源: DOAJ

【 摘 要 】

Abstract Background The purpose of this study was to assess the prognostic performance of the log odds of positive lymph nodes (LODDS) value compared with the pathological N stage and lymph node ratio (LNR) in patients with esophageal squamous cell carcinoma (ESCC). Method In total 1144 patients diagnosed with ESCC from the Surveillance, Epidemiology, and End Results (SEER) database and 930 patients from our validation cohort were eligible. Kaplan–Meier plotter and multivariate Cox proportional hazards models were conducted to investigate the prognostic value of the N stage, LNR stage, and LODDS stage. The homogeneity, discriminatory ability, and monotonicity of these variables were evaluated using the linear trend χ2 test, likelihood ratio χ2 test, Akaike information criterion (AIC), and consistency index (C‐index) to determine the potential superiorities. Results The prognostic LODDS cutoff values were determined to be −1.49 and −0.55 (p < 0.001). Univariate analyses showed significant association among the N, LNR, and LODDS stages and overall survival of the patients (all p < 0.001). Multivariate analyses confirmed that the LODDS stage remained an independent prognostic indicator in both the SEER database and our validation cohort. Subgroup analyses identified the ability of LODDS stage to distinguish heterogeneous patients within various groups in both independent databases. Furthermore, the model with the highest C‐index and smallest AIC value was the one incorporating the LODDS stage among the three investigated nodal classifications of both cohorts. Conclusion The novel LODDS stage demonstrated better prognostic performance than the traditional N or LNR stages in ESCC patients. It can serve as an auxiliary factor to improve prognostic performance and can be applied to evaluate the lymph node status to increase the precision of staging and evaluation of survival.

【 授权许可】

Unknown