期刊论文详细信息
Frontiers in Neuroscience
Tracking the Effect of Cathodal Transcranial Direct Current Stimulation on Cortical Excitability and Connectivity by Means of TMS-EEG
Alessandra Vergallito2  Alberto Pisoni2  Lilia D. Mauro2  Leonor J. Romero Lauro2  Alessia Gallucci2  Giulia C. Mattavelli2  Mario Rosanova3  Nadia Bolognini4  Giuseppe Vallar4  Erica Varoli5 
[1] Department of Biomedical and Clinical Sciences “L. Sacco”, University of Milan, Milan, Italy;Department of Psychology, University of Milano-Bicocca, Milan, Italy;Fondazione Europea per la Ricerca Biomedica Onlus, Milan, Italy;Laboratory of Neuropsychology, IRCCS Istituto Auxologico, Milan, Italy;NeuroMi - Milan Center of Neuroscience, Milan, Italy;Ph.D. Program in Neuroscience, Department of Medicine and Surgery, University Milano-Bicocca, Monza, Italy;
关键词: cathodal tDCS;    TMS-EEG;    cortical excitability;    posterior parietal cortex;    neuromodulation;   
DOI  :  10.3389/fnins.2018.00319
来源: DOAJ
【 摘 要 】

Transcranial direct current stimulation (tDCS) is increasingly used in both research and therapeutic settings, but its precise mechanisms remain largely unknown. At a neuronal level, tDCS modulates cortical excitability by shifting the resting membrane potential in a polarity-dependent way: anodal stimulation increases the spontaneous firing rate, while cathodal decreases it. However, the neurophysiological underpinnings of anodal/cathodal tDCS seem to be different, as well as their behavioral effect, in particular when high order areas are involved, compared to when motor or sensory brain areas are targeted. Previously, we investigated the effect of anodal tDCS on cortical excitability, by means of a combination of Transcranial Magnetic Stimulation (TMS) and Electroencephalography (EEG). Results showed a diffuse rise of cortical excitability in a bilateral fronto-parietal network. In the present study, we tested, with the same paradigm, the effect of cathodal tDCS. Single pulse TMS was delivered over the left posterior parietal cortex (PPC), before, during, and after 10 min of cathodal or sham tDCS over the right PPC, while recording HD-EEG. Indexes of global and local cortical excitability were obtained both at sensors and cortical sources level. At sensors, global and local mean field power (GMFP and LMFP) were computed for three temporal windows (0–50, 50–100, and 100–150 ms), on all channels (GMFP), and in four different clusters of electrodes (LMFP, left and right, in frontal and parietal regions). After source reconstruction, Significant Current Density was computed at the global level, and for four Broadmann's areas (left/right BA 6 and 7). Both sensors and cortical sources results converge in showing no differences during and after cathodal tDCS compared to pre-stimulation sessions, both at global and local level. The same holds for sham tDCS. These data highlight an asymmetric impact of anodal and cathodal stimulation on cortical excitability, with a diffuse effect of anodal and no effect of cathodal tDCS over the parietal cortex. These results are consistent with the current literature: while anodal-excitatory and cathodal-inhibitory effects are well-established in the sensory and motor domains, both at physiological and behavioral levels, results for cathodal stimulation are more controversial for modulation of exitability of higher order areas.

【 授权许可】

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