Anti-Adipogenic Polyacetylene Glycosides from the Florets of Safflower (Carthamus tinctorius)

Biomedicines

TaeSu Jang¹  Jin-Chul Kim²  Changhyun Pang³  SangAh Yi⁴  BumSoo Lee⁴  JaeSik Yu⁴  KiHyun Kim⁴  Jaecheol Lee⁴  SuCheol Baek⁴ 

[1] Department of Medicine, Dankook University, Cheonan, Chungnam 31116, Korea;Natural Product Informatics Research Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, Korea;School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea;School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea;

关键词: safflower;    Carthamus tinctorius;    polyacetylene glycosides;    3T3-L1 preadipocytes;    AMPK;   

DOI  :  10.3390/biomedicines9010091

来源: DOAJ

【 摘 要 】

Safflower (Carthamus tinctorius) is an annual herb belonging to the Compositae family; it has a history of use as a food colorant, dye, and medicine in oriental countries. LC-MS-UV-based chemical analysis of extract of the florets of C. tinctorius led to the isolation of two new C₁₀-polyacetylene glycosides, (8Z)-decaene-4,6-diyne-1,10-diol-1-O-β-d-glucopyranoside (1) and (8S)-deca-4,6-diyne-1,8-diol-1-O-β-d-glucopyranoside (2), together with five known analogs (3–7). The structures of the new compounds were determined by using 1D and 2D NMR spectroscopic data and HR-MS data, as well as chemical transformations. Of compounds 1–7, compounds 2, 3, and 4 inhibited the adipogenesis of 3T3-L1 preadipocytes, whereas compounds 1 and 6 promoted adipogenesis. Compounds 2, 3, and 4 also prevented lipid accumulation through the suppression of the expression of lipogenic genes and the increase of the expression of lipolytic genes. Moreover, compounds 3 and 4 activated AMPK, which is known to facilitate lipid metabolism. Our findings provide a mechanistic rationale for the use of safflower-derived polyacetylene glycosides as potential therapeutic agents against obesity.

【 授权许可】

Unknown