Autophagy Dysregulation in Diabetic Kidney Disease: From Pathophysiology to Pharmacological Interventions

Cells

María Paula Carro Negueruela¹  Catalina Nicora Santamarina¹  Claudio D. Gonzalez²  Roxana Resnik²  Maria I. Vaccaro² 

[1] Instituto Universitario del Centro de Educacion Medica e Investigacion Clinica (IUC-CEMIC-CONICET), Facultad de Medicina, Instituto Universitario CEMIC, Buenos Aires C1430 EFA, Argentina;Instituto de Bioquimica y Medicina Molecular Prof. Alberto Boveris (UBA-CONICET), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires C1113 AAD, Argentina;

关键词: diabetic kidney disease;    autophagy;    pharmacological treatment;    podocytes;    proximal-tubular cells;    metformin;   

DOI  :  10.3390/cells10092497

来源: DOAJ

【 摘 要 】

Diabetic kidney disease (DKD) is a frequent, potentially devastating complication of diabetes mellitus. Several factors are involved in its pathophysiology. At a cellular level, diabetic kidney disease is associated with many structural and functional alterations. Autophagy is a cellular mechanism that transports intracytoplasmic components to lysosomes to preserve cellular function and homeostasis. Autophagy integrity is essential for cell homeostasis, its alteration can drive to cell damage or death. Diabetic kidney disease is associated with profound autophagy dysregulation. Autophagy rate and flux alterations were described in several models of diabetic kidney disease. Some of them are closely linked with disease progression and severity. Some antidiabetic agents have shown significant effects on autophagy. A few of them have also demonstrated to modify disease progression and improved outcomes in affected patients. Other drugs also target autophagy and are being explored for clinical use in patients with diabetic kidney disease. The modulation of autophagy could be relevant for the pharmacological treatment and prevention of this disease in the future. Therefore, this is an evolving area that requires further experimental and clinical research. Here we discuss the relationship between autophagy and Diabetic kidney disease and the potential value of autophagy modulation as a target for pharmacological intervention.

【 授权许可】

Unknown