Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment

Brain Sciences

Gelsomina Mansueto¹  Afshin A. Divani²  Santiago Ortega-Gutierrez³  Chiara Rocchi⁴  Mauro Silvestrini⁴  Davide Norata⁴  Simona Lattanzi⁴  Serena Broggi⁴  Mario Di Napoli⁵ 

[1] Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy;Department of Neurology, University of New Mexico, Albuquerque, NM 87131, USA;Departments of Neurology, Neurosurgery, and Radiology, University of Iowa, Iowa City, IA 52242, USA;Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, 60020 Ancona, Italy;Neurological Service, SS Annunziata Hospital, Sulmona, 67039 L’Aquila, Italy;

关键词: cerebrovascular disease;    endovascular treatment;    intravenous thrombolysis;    inflammation;    ischemic stroke;    lymphocyte;   

DOI  :  10.3390/brainsci11091164

来源: DOAJ

【 摘 要 】

Futile recanalization remains a significant challenge for endovascular treatment (EVT) of acute ischemic stroke (AIS). The inflammatory response that occurs after cerebral infarct plays a central role in stroke pathobiology that can influence the outcome of a recanalization procedure. The aim of this study was to evaluate the relationship between the systemic inflammatory response index (SIRI) and futile recanalization in patients with AIS. We retrospectively identified consecutive patients with ischemic stroke due to proximal arterial occlusion in the anterior circulation, who were treated with EVT and achieved near-complete or complete recanalization. Absolute neutrophil count (ANC), absolute monocyte count (AMC), and absolute lymphocyte count (ALC) were collected from admission blood work to calculate SIRI as ANC × AMC/ALC. The study outcome was futile recanalization, defined as poor functional status [modified Rankin scale (mRS) score ≥ 3] at 3 months despite complete or near-complete recanalization. A total of 184 patients were included. Futile recanalization was observed in 110 (59.8%) patients. Older patients (odds ratio (OR) = 1.07, 95% confidence interval (CI): 1.04–1.10, p < 0.001), higher admission National Institutes of Health stroke scale score (OR = 1.10, 95% CI: 1.02–1.19, p = 0.013), and higher admission SIRI (OR = 1.08, 95% CI: 1.01–1.17, p = 0.028) increased the risk of the poor outcome at 3 months despite complete or near-complete recanalization.

【 授权许可】

Unknown