Evaluation of the Effectiveness and Safety of the BNT162b2 COVID-19 Vaccine in the Vaccination Campaign among the Health Workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS

International Journal of Environmental Research and Public Health

Andrea Cambieri¹  Maurizio Zega¹  Francesco Maria De Simone¹  Mario Cesare Nurchis²  Angelo Maria Pezzullo²  Patrizia Laurenti²  Domenico Pascucci²  Nadia Mores²  Gianfranco Damiani²  Flavia Beccia²  Martina Sapienza²  Carolina Castagna²  Adriano Grossi²  Floriana D’Ambrosio²  Domenico Staiti²  Francesco Castrini²  Giuseppe Vetrugno² 

[1] Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy;Università Cattolica del Sacro Cuore, 00168 Rome, Italy;

关键词: effectiveness;    safety;    health workers;    vaccine;    vaccination campaign;    COVID-19;   

DOI  :  10.3390/ijerph182111098

来源: DOAJ

【 摘 要 】

Health workers, especially those in patient-facing roles, had a significantly increased risk of COVID-19 infection, having serious outcomes, and risking spreading the virus to patients and staff. Vaccination campaign planning suggests allocating initial supplies of BNT162b2 vaccine to health workers given the importance of early protection to safeguard the continuity of care to patients. The aim of the study is to assess the effectiveness and safety of BNT162b2 vaccine among the health workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS (FPG). The retrospective cohort study was conducted among health staff working at the FPG. Vaccination data were collected from hospital records. The primary end points were vaccine effectiveness and safety. A total of 6649 health workers were included, of whom 5162 received injections. There were 14 cases of COVID-19 with onset at least 14 days after the second dose among vaccinated health workers and 45 cases among unvaccinated ones. BNT162b2 was 91.5% effective against COVID-19 (95% credible interval, 84.7% to 95.3%). The safety profile of BNT162b2 vaccine consisted of short-term, non-serious events. The promotion and boost of the COVID-19 vaccination campaign represents a key public health measure useful to curb the spread of the pandemic especially in vulnerable contexts, such as hospitals, where health workers carry out a paramount role for the entire community, and requires further protection with a possible booster dose in view of autumn-winter 2021.

【 授权许可】

Unknown