Biologic Therapy and Severe Asthma in Children

Biomedicines

Mauro Lizzi¹  Daniele Russo¹  Marina Attanasi¹  Francesco Chiarelli¹  Paola Di Filippo¹  Sabrina Di Pillo¹ 

[1] Department of Pediatrics, University of Chieti, 66100 Chieti, Italy;

关键词: severe asthma;    children;    biologic therapy;    endotype;    phenotype;   

DOI  :  10.3390/biomedicines9070760

来源: DOAJ

【 摘 要 】

Severe asthma is a heterogeneous, complex and chronic disease widespread in the pediatric population. According to the recent findings about the different endotypes of asthma in children, each one characterized by specific intracellular molecular pathways, several innovative biologic therapies have been developed. Due to their precise ability to target specific inflammatory type 2 mediators, biologics have revolutionized the care of chronic allergic diseases in the pediatric and adult population. In this review, we aim to provide the latest evidence about the use, indications, efficacy and safety of biologic therapies to treat severe asthma in children and adolescents.

【 授权许可】

Unknown