期刊论文详细信息
Molbank | |
(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one | |
Nicola Della Ca’1  Mariangela Novello2  Ida Ziccarelli2  Bartolo Gabriele2  Raffaella Mancuso2  Rossana Miliè2  | |
[1] Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA), University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy;Laboratory of Industrial and Synthetic Organic Chemistry, Department of Chemistry and Chemical Technologies, University of Calabria, Via Pietro Bucci 12/C, 87036 Arcavacata di Rende (CS), Italy; | |
关键词: β-amino alcohols; carbonylation; cyclocarbonylation; oxazolidinones; palladium; | |
DOI : 10.3390/M1017 | |
来源: DOAJ |
【 摘 要 】
(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one has been synthesized for the first time by the enantiospecific oxidative carbonylation of commercially available (S)-2-amino-3-methyl-1,1-diphenylbutan-1-ol. The cyclocarbonylation reaction was carried out at 100 °C in 1,2-dimethoxyethane (DME) as the solvent for 15 h, under 20 atm of a 4:1 mixture of CO–air and in the presence of the catalytic system PdI2/KI (substrate:KI:PdI2 molar ratio = 100:10:1), to give the oxazolidinone derivative in 81% isolated yield.
【 授权许可】
Unknown