Functional topography of the human entorhinal cortex

eLife

Christian F Doeller¹  Tobias Navarro Schröder²  Christian F Beckmann²  Nestor I Zaragoza Jimenez²  Koen V Haak² 

[1] Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands;Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands;

关键词: entorhinal cortex;    medial temporal lobe;    fMRI;   

DOI  :  10.7554/eLife.06738

来源: DOAJ

【 摘 要 】

Despite extensive research on the role of the rodent medial and lateral entorhinal cortex (MEC/LEC) in spatial navigation, memory and related disease, their human homologues remain elusive. Here, we combine high-field functional magnetic resonance imaging at 7 T with novel data-driven and model-based analyses to identify corresponding subregions in humans based on the well-known global connectivity fingerprints in rodents and sensitivity to spatial and non-spatial information. We provide evidence for a functional division primarily along the anteroposterior axis. Localising the human homologue of the rodent MEC and LEC has important implications for translating studies on the hippocampo-entorhinal memory system from rodents to humans.

【 授权许可】

Unknown