Diagnostic Roles of Postmortem cTn I and cTn T in Cardiac Death with Special Regard to Myocardial Infarction: A Systematic Literature Review and Meta-Analysis

International Journal of Molecular Sciences

Mengyang Zhao¹  Tianyi Zhang²  Tianqi Wang²  Yuqing Jia²  Zhipeng Cao²  Baoli Zhu²  Chengyang Xu³ 

[1] Department of Forensic Genetics and Biology, School of Forensic Medicine, China Medical University, Shenyang 110122, China;Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122, China;The Third Clinical Department of China Medical University, Shenyang 110122, China;

关键词: forensic medicine;    medical laboratory science;    postmortem biochemistry;    cardiac death;    myocardial infarction;    postmortem;    cTn I;    cTn T;    cut-off value;    meta-analysis;   

DOI  :  10.3390/ijms20133351

来源: DOAJ

【 摘 要 】

Background: Cardiac troponin I (cTn I) and cardiac troponin T (cTn T) are currently widely used as diagnostic biomarkers for myocardial injury caused by ischemic heart diseases in clinical and forensic medicine. However, no previous meta-analysis has summarized the diagnostic roles of postmortem cTn I and cTn T. The aim of the present study was to meta-analyze the diagnostic roles of postmortem cTn I and cTn T for cardiac death in forensic medicine, present a systematic review of the previous literature, and determine the postmortem cut-off values of cTn I and cTn T. Methods: We searched multiple databases for the related literature, performed a meta-analysis to investigate the diagnostic roles of postmortem cardiac troponins, and analyzed the receiver operating characteristic (ROC) curve to determine their postmortem cut-off values. Results and Conclusions: The present meta-analysis demonstrated that postmortem cTn I and cTn T levels were increased in pericardial fluid and serum in cardiac death, especially in patients with acute myocardial infarction (AMI). We determined the postmortem cut-off value of cTn I in the pericardial fluid at 86.2 ng/mL, cTn I in serum at 9.5 ng/mL, and cTn T in serum at 8.025 ng/mL.

【 授权许可】

Unknown