Differential Phenotypes in Perivascular Adipose Tissue Surrounding the Internal Thoracic Artery and Diseased Coronary Artery

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Masanori Nakamura¹  Hirosato Doi²  Ryosuke Numaguchi²  Toshiro Ito²  Yosuke Kuroda²  Ryo Harada²  Nobuyoshi Kawaharada²  Hiroshi Sato²  Yosuke Yanase²  Yukimura Higashiura³  Tetsuji Miura³  Megumi Matsumoto³  Masayuki Koyama³  Masato Furuhashi³  Norihito Moniwa³  Marenao Tanaka³ 

[1] Department of Cardiovascular Surgery Sapporo City General Hospital Sapporo Japan;Department of Cardiovascular Surgery Sapporo Medical University School of Medicine Sapporo Japan;Department of Cardiovascular, Renal and Metabolic Medicine Sapporo Medical University School of Medicine Sapporo Japan;

关键词: adipokine;    adipose tissue;    atherosclerosis;    coronary artery bypass graft;    fibrosis;   

DOI  :  10.1161/JAHA.118.011147

来源: DOAJ

【 摘 要 】

Background Perivascular adipose tissue (PVAT) is causally associated with vascular function and the pathogenesis of vascular disease in association with metabolically driven chronic inflammation called metaflammation. However, the difference in PVAT surrounding the coronary artery (CA‐PVAT) and that surrounding the internal thoracic artery (ITA‐PVAT), a vessel resistant to atherosclerosis, remains unclear. Herein, we investigated whether CA‐PVAT, ITA‐PVAT, and subcutaneous adipose tissue (SCAT) have distinct phenotypes. Methods and Results Fat pads were sampled from 44 patients (men/women, 36:8; age, 67±13 years) with CA disease who underwent elective CA bypass grafting. Adipocyte size in ITA‐PVAT and that in CA‐PVAT were significantly smaller than that in SCAT. A greater extent of fibrosis and increased gene expression levels of fibrosis‐related molecules were observed in CA‐PVAT than those in SCAT and those in ITA‐PVAT. CA‐PVAT exhibited more pronounced metaflammation, as indicated by a significantly larger extent of CD68‐positive and CD11c‐positive M1 macrophages, a lower ratio of CD206‐positive M2 to CD11c‐positive M1 macrophages, a lower gene expression level of adiponectin, and higher gene expression levels of inflammatory cytokines and inflammasome‐ and endoplasmic reticulum stress–related molecules, than did ITA‐PVAT and SCAT. Expression patterns of adipocyte developmental and pattern‐forming genes were totally different among SCAT, ITA‐PVAT, and CA‐PVAT. Conclusions The phenotype of ITA‐PVAT is closer to that of SCAT than that of CA‐PVAT, which may result from inherent differences in adipocytes. ITA‐PVAT appears to be protected from metaflammation and consecutive adipose tissue remodeling, which may contribute to the decreased atherosclerotic plaque burden in the ITA.

【 授权许可】

Unknown