Drug-eluting coating of extruded polymeric tubular microstructures

Current Directions in Biomedical Engineering

Guthoff Rudolf¹  Bajer Dalibor²  Reske Thomas²  Arbeiter Daniela²  Grabow Niels²  Sahmel Olga²  Siewert Stefan³  Schmitz Klaus-Peter⁴  Friederike Kreiner Christine⁵ 

[1] Department of Ophthalmology, Rostock University Medical Center, Doberaner Str. 140, 18057Rostock, Germany;Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, 18119Rostock, Germany;Institute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, Germany;Institute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119Rostock-Warnemünde, Germany;KreCo Kreiner Consulting Society for scientific and technical project management mbH, 16761Hennigsdorf, Germany;

关键词: extrusion;    plla;    sil;    tubular semi-finished product;    drug eluting;    resveratrol;    release study;   

DOI  :  10.1515/cdbme-2021-2112

来源: DOAJ

【 摘 要 】

Extrusion is a common manufacturing process for semi-finished polymer products in various biomedical applications. Extrusion enables processing of a wide range of biomaterials, as well as different cross-sectional geometries. Furthermore, feasibility of drug elution, as it is used for a variety of medical devices, for example microstents for minimally invasive glaucoma therapy, was assessed. The current study deals with manufacturing of polymeric microtubes by extrusion processing. Semi-finished products were made of biodegradable poly-L-lactide (PLLA) and a non-biodegradable polycarbonate-based silicone elastomer (SIL) and covered with a polymer/drug combination, with resveratrol as active ingredient. Three different concentrations of polymer/resveratrol were applied by means of spray-coating. The release behavior of active ingredient was analyzed in vitro at 37°C and showed a correlation between the amount of drug and release time. With higher drug content, a faster release was observed. In addition, the release from SIL was faster compared with PLLA.

【 授权许可】

Unknown