Complete remission of advanced lung adenocarcinoma with first-line pembrolizumab monotherapy: Two case reports

Respiratory Medicine Case Reports

Keiichi Iwasa¹  Yoshihiro Takeda²  Kazuki Gohara³  Kazuhiko Shibata³  Akihito Okazaki³ 

[1] Corresponding author. Department of Respiratory Medicine, Kaga Medical Center, Ri-36 Sakumi-machi, Kaga, Ishikawa, 922-8522, Japan.;Department of Respiratory Medicine, Kaga Medical Center, Ri-36 Sakumi-machi, Kaga, 922-8522, Japan;Department of Respiratory Medicine, Koseiren Takaoka Hospital, 5-10 Eiraku-machi, Takaoka, 933-8555, Japan;

关键词: Complete remission;    Immunotherapy;    Lung adenocarcinoma;    Pembrolizumab;   

DOI  :  

来源: DOAJ

【 摘 要 】

Immune checkpoint inhibitors (ICIs) are clinically used for treating advanced lung cancer, and some patients have achieved complete remission (CR) with ICI therapy in clinical trials. However, reports summarizing the clinical courses of such patients are limited. We report two cases of lung adenocarcinoma in which CR was achieved with first-line pembrolizumab monotherapy, and the therapeutic effect was maintained after treatment completion. Specific patients can achieve CR, even those who do not meet the previously reported predictors of treatment response other than high programmed death-ligand 1 expression. Thus, biomarkers that can accurately predict the clinical efficacy of ICIs are warranted.

【 授权许可】

Unknown