Transmembrane 163 (TMEM163) Protein: A New Member of the Zinc Efflux Transporter Family

Biomedicines

Math P. Cuajungco¹  Daniel J. Styrpejko¹ 

[1] Department of Biological Science, California State University Fullerton, Fullerton, CA 92831, USA;

关键词: zinc;    cation diffusion facilitator;    zinc transporter;    SV31;   

DOI  :  10.3390/biomedicines9020220

来源: DOAJ

【 摘 要 】

A growing body of evidence continues to demonstrate the vital roles that zinc and its transporters play on human health. The mammalian solute carrier 30 (SLC30) family, with ten current members, controls zinc efflux transport in cells. TMEM163, a recently reported zinc transporter, has similar characteristics in both predicted transmembrane domain structure and function to the cation diffusion facilitator (CDF) protein superfamily. This review discusses past and present data indicating that TMEM163 is a zinc binding protein that transports zinc in cells. We provide a brief background on TMEM163’s discovery, transport feature, protein interactome, and similarities, as well as differences, with known SLC30 (ZnT) protein family. We also examine recent reports that implicate TMEM163 directly or indirectly in various human diseases such as Parkinson’s disease, Mucolipidosis type IV and diabetes. Overall, the role of TMEM163 protein in zinc metabolism is beginning to be realized, and based on current evidence, we propose that it is likely a new CDF member belonging to mammalian SLC30 (ZnT) zinc efflux transporter proteins.

【 授权许可】

Unknown