Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential

Frontiers in Cell and Developmental Biology

Ken J. Ishii²  Manami Toriyama⁴ 

[1] Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan;Division of Vaccine Science, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan;Graduate School of Pharmacological Sciences, Osaka University, Osaka, Japan;Graduate School of Science and Technology, Nara Institute of Science and Technology, Nara, Japan;Laboratory of Vaccine Science, World Premier International Research Center Initiative (WPI) Immunology Frontier Research Center, Osaka University, Osaka, Japan;

关键词: primary cilia;    immunity;    epidermis;    atopic dermatitis;    keratinocyte;    Langerhans cell;   

DOI  :  10.3389/fcell.2021.621318

来源: DOAJ

【 摘 要 】

The skin is the biggest organ and provides a physical and immunological barrier against pathogen infection. The distribution of primary cilia in the skin of mice has been reported, but which cells in human skin have them has not, and we still know very little about how they change in response to immune reactions or disease. This review introduces several studies that describe mechanisms of cilia regulation by immune reaction and the physiological relevance of cilia regulating proliferation and differentiation of stroma cells, including skin-resident Langerhans cells. We discuss the possibility of primary cilia pathology in allergic atopic dermatitis and the potential for therapies targeting primary cilia signaling.

【 授权许可】

Unknown