Formulation Design and Experiment Interpretation through TorqueMeasurements in High-Shear Wet Granulation

KONA Powder and Particle Journal

Paolo Canu¹  Mauro Cavinato¹  Andrea C. Santomaso¹ 

[1] DIPIC, Department of Chemical Engineering, University ofPadova;

关键词: wet granulation;    high shear mixer;    glass transition;    hydrophobic active ingredient;   

DOI  :  10.14356/kona.2011020

来源: DOAJ

【 摘 要 】

High-shear wet granulation is commonly used in many industries such as in thepharmaceutical industry to convert fine cohesive powders into dense and roundgranules. The purpose of this work was to determine the effects of someimportant powder properties (crystalline or amorphous nature, hygroscopicity,solubility and particle size) and process variables (liquid addition rate,impeller speed) on the early stages of the granulation process and on drugdistribution in granules obtained by high-shear wet granulation. The glasstransition concept coupled with on-line impeller torque monitoring andmeasurements of the time evolution of the particle size distribution were usedto study mixtures of pharmaceutical excipients and some common activeingredients. In particular a formulation map for estimating the minimum amountof liquid binder required to induce appreciable granule growth is presented,thus outlining a new method to considerably increase the predictability of thebehaviour of different formulations on the basis of the physical properties ofeach single component. The description of the effects of the wetting conditionon drug uniformity content in some formulations with hydrophobic activeingredients is given as well.

【 授权许可】

Unknown