Recent Advances in Cardiac Tissue Engineering for the Management of Myocardium Infarction

Cells

Vijay Kumar Thakur¹  Kavindra Kumar Kesari²  Janne Ruokolainen²  Dillip Kumar Bishi³  Niraj Kumar Jha⁴  Rekha Gahtori⁵  Richa Tomar⁶  Nidhi Negi⁷  Abhijit Dey⁸  Piyush Kumar Gupta⁹  Shreesh Ojha^1,10  Kamal Dua^1,11  Rohit Gundamaraju^1,12  Sanat Kumar Dash^1,13  Mahmood Barani^1,14  Sudip Chakraborty^1,15  Sachin Kumar Singh^1,16  Poonam Negi^1,17  Kavitha Govarthanan^1,18  Vineeta Sharma^1,18  Santosh Mathapati^1,19 

[1] Biorefining and Advanced Materials Research Centre, Scotland’s Rural College (SRUC), Kings Buildings, Edinburgh EH9 3JG, UK;Department of Applied Physics, School of Science, Aalto University, 00076 Espoo, Finland;Department of Biotechnology, Rama Devi Women’s University, Bhubaneswar 751022, India;Department of Biotechnology, School of Engineering and Technology, Sharda University, Knowledge Park III, Greater Noida 201310, India;Department of Biotechnology, Sir J. C. Bose Technical Campus, Kumaun University, Nainital 263136, India;Department of Chemistry and Biochemistry, School of Basic Sciences and Research, Sharda University, Knowledge Park III, Greater Noida 201310, India;Department of Chemistry, DSB Campus, Kumaun University, Nainital 263001, India;Department of Life Sciences, Presidency University, College Street, Kolkata 700073, India;Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Knowledge Park III, Greater Noida 201310, India;Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates;Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Sydney, NSW 2007, Australia;ER Stress and Mucosal Immunology Laboratory, School of Health Sciences, University of Tasmania, Launceston, TAS 7248, Australia;Heat Transfer and Thermal Power Laboratory, Department of Mechanical Engineering, Indian Institute of Technology Madras, Chennai 600036, India;Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman 7616913555, Iran;School of Chemistry, University of New South Wales, Anzac Parade, Kensington, NSW 2033, Australia;School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144001, India;School of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173212, India;Stem Cell and Molecular Biology Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Bhupat and Jyoti Mehta School of Biosciences, Chennai 600036, India;Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurugram Expressway, Faridabad 121001, India;

关键词: myocardial infarction;    stem cells;    regeneration;    biomaterial;    cardiomyocytes;    tissue engineering;   

DOI  :  10.3390/cells10102538

来源: DOAJ

【 摘 要 】

Myocardium Infarction (MI) is one of the foremost cardiovascular diseases (CVDs) causing death worldwide, and its case numbers are expected to continuously increase in the coming years. Pharmacological interventions have not been at the forefront in ameliorating MI-related morbidity and mortality. Stem cell-based tissue engineering approaches have been extensively explored for their regenerative potential in the infarcted myocardium. Recent studies on microfluidic devices employing stem cells under laboratory set-up have revealed meticulous events pertaining to the pathophysiology of MI occurring at the infarcted site. This discovery also underpins the appropriate conditions in the niche for differentiating stem cells into mature cardiomyocyte-like cells and leads to engineering of the scaffold via mimicking of native cardiac physiological conditions. However, the mode of stem cell-loaded engineered scaffolds delivered to the site of infarction is still a challenging mission, and yet to be translated to the clinical setting. In this review, we have elucidated the various strategies developed using a hydrogel-based system both as encapsulated stem cells and as biocompatible patches loaded with cells and applied at the site of infarction.

【 授权许可】

Unknown