The Interplay between MicroRNAs and the Components of the Tumor Microenvironment in B-Cell Malignancies

International Journal of Molecular Sciences

Sherien M. El-Daly¹  Simone Anfossi¹  George A. Calin¹  Recep Bayraktar¹ 

[1] Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;

关键词: B-cell malignancies;    tumor microenvironment;    stroma;    microRNAs;    cell-to-cell communication;    exosomal miRNAs;   

DOI  :  10.3390/ijms21093387

来源: DOAJ

【 摘 要 】

An increased focus is being placed on the tumorigenesis and contexture of tumor microenvironment in hematopoietic and solid tumors. Despite recent clinical revolutions in adoptive T-cell transfer approaches and immune checkpoint blockade, tumor microenvironment is a major obstacle to tumor regression in B-cell malignancies. A transcriptional alteration of coding and non-coding RNAs, such as microRNAs (miRNAs), has been widely demonstrated in the tumor microenvironment of B-cell malignancies. MiRNAs have been associated with different clinical-biological forms of B-cell malignancies and involved in the regulation of B lymphocyte development, maturation, and function, including B-cell activation and malignant transformation. Additionally, tumor-secreted extracellular vesicles regulate recipient cell functions in the tumor microenvironment to facilitate metastasis and progression by delivering miRNA contents to neighboring cells. Herein, we focus on the interplay between miRNAs and tumor microenvironment components in the different B-cell malignancies and its impact on diagnosis, proliferation, and involvement in treatment resistance.

【 授权许可】

Unknown