Amyotrophic lateral sclerosis – aetiology,diagnostics and multidirectional, team, long-term care

Journal of Education, Health and Sport

Katarzyna Schab¹  Magdalena Urbańczuk¹  Marcin Urbańczuk²  Kamila Tuzim³  Tomasz Tuzim⁴ 

[1] ;Chair and Department of Clinical Pathomorphology of the Medical University of Lublin, ul. Jaczewskiego 8b, Lublin 20-090, Poland;Chair and Department of Clinical Pathomorphology of the Medical University of Lublin;Sanus Specialist Hospital, ul. Wojska Polskiego 4, Stalowa Wola, Poland;

关键词: amyotrophic lateral sclerosis, als, electrophysiological examination, riluzole, edaravone, replacement ventilation.;   

DOI  :  10.5281/zenodo.1343951

来源: DOAJ

【 摘 要 】

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease of brain motoneurons and spinal cord. The incidence rate of this completely incurable condition amounts to 3 to 5 patients per 100,000 inhabitants and its characteristic feature is progressing muscle weakening that leads to respiratory muscle paralysis and death within 3-4 years. Up to now, etiopathogenesis of ALS is unknown, however, more and more often the role of genotype interaction with environmental factors is suggested. Diagnosing ALS is still based on a correlation of interview and clinical picture with the results of diagnostic imaging, electrophysiological examinations and some serological tests. Despite an enormous progress that occurred in neurobiology and molecular genetics, an effective pharmacotherapy inhibiting the development of the disease has not been developed yet, and the treatment is exclusively based on a systematic symptomatic management. Due to the above, ALS treatment is still a great challenge both for the scientists and clinicians.

【 授权许可】

Unknown