Comparison of two commercial tests (Immy vs. Dynamiker) for cryptococcal capsular antigen

Revista da Sociedade Brasileira de Medicina Tropical

关键词: Lateral flow assay;    CrAg-LFA;    IMMY;    Dynamiker;    Point-of-Care test;    Diagnostic performance;   

DOI  :  10.1590/0037-8682-0307-2021

来源: DOAJ

【 摘 要 】

AbstractINTRODUCTIONLateral flow assay is an advanced method useful in the early diagnosis of cryptococcal meningitis. We aimed to compare two commercial tests for cryptococcal capsular antigen in the sera of asymptomatic patients with human immunodeficiency virus in Barranquilla, Colombia.METHODSThawed (n=162) previously collected serums (2016-2019) were processed using IMMY and Dynamiker cryptococcal antigen lateral flow assay.RESULTSCompared to IMMY’s results, Dynamiker’s sensitivity, specificity, positive predictive value, negative predictive value, and kappa index were 100%, 89.9%, 48.3%, 100.0%, and 0.61, respectively.CONCLUSIONSThe Dynamiker test had excellent sensitivity, acceptable specificity, and a low detection threshold for cryptococcal antigen in the tested samples.

【 授权许可】

Unknown