Potential Antiviral Strategy Exploiting Dependence of SARS-CoV-2 Replication on Lysosome-Based Pathway

International Journal of Molecular Sciences

Gaili Wang¹  Yuzhu Chen²  Deguang Song²  Zhenzhen Wang²  Feng Gao²  Yungang Lan²  Wenqi He² 

[1] Jilin Academy of Animal Husbandry and Veterinary Medicine, Changchun 130022, China;Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130022, China;

关键词: SARS-CoV-2 replication;    lysosomal function;    CTSL activities;    lysosomal acidification;   

DOI  :  10.3390/ijms23116188

来源: DOAJ

【 摘 要 】

The recent novel coronavirus (SARS-CoV-2) disease (COVID-19) outbreak created a severe public health burden worldwide. Unfortunately, the SARS-CoV-2 variant is still spreading at an unprecedented speed in many countries and regions. There is still a lack of effective treatment for moderate and severe COVID-19 patients, due to a lack of understanding of the SARS-CoV-2 life cycle. Lysosomes, which act as “garbage disposals” for nearly all types of eukaryotic cells, were shown in numerous studies to support SARS-CoV-2 replication. Lysosome-associated pathways are required for virus entry and exit during replication. In this review, we summarize experimental evidence demonstrating a correlation between lysosomal function and SARS-CoV-2 replication, and the development of lysosomal perturbation drugs as anti-SARS-CoV-2 agents.

【 授权许可】

Unknown