Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study

Nutrients

Salvatore Corrao¹  Giuseppe Licata¹  Diego Pancaldo²  Concetta Irace³  Cesare de Gregorio⁴  Giacoma Di Vieste⁴  Herbert Marini⁴  Marco Atteritano⁴  Vincenzo Arcoraci⁴  Antonino Di Benedetto⁴  Francesco Squadrito⁴  Alessandra Bitto⁴  Angela Alibrandi⁵  Elena Bianca Adamo⁶  Roberta Granese⁷  Domenica Altavilla⁷ 

[1] Centre of Research for Effectiveness and Appropriateness in Medicine (C.R.E.A.M.), Di.Bi.M.I.S., University of Palermo, 90127 Palermo, Italy;Department of Cardiology, SS. Annunziata Hospital, 12038 Savigliano (CN), Italy;Department of Clinical and Experimental Medicine, University Magna Græcia, 88100 Catanzaro, Italy;Department of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy;Department of Economics, Business, Environmental Science and Quantitative Methodologies, University of Messina, 98100 Messina, Italy;Department of Experimental, Specialized Medical and Surgical and Odonto-stomatological Sciences, University of Messina, 98100 Messina, Italy;Department of Pediatric, Gynecological, Microbiological, and Biomedical Sciences, University of Messina, 98100 Messina, Italy;

关键词: genistein;    metabolic syndrome;    menopause;    cardiac function;    echocardiography;   

DOI  :  10.3390/nu9060584

来源: DOAJ

【 摘 要 】

Genistein, a soy-derived isoflavone, may improve cardiovascular risk profile in postmenopausal women with metabolic syndrome (MetS), but few literature data on its cardiac effects in humans are available. The aim of this sub-study of a randomized double-blind case-control study was to analyze the effect on cardiac function of one-year genistein dietary supplementation in 22 post-menopausal patients with MetS. Participants received 54 mg/day of genistein (n = 11) or placebo (n = 11) in combination with a Mediterranean-style diet and regular exercise. Left ventricular (LV) systolic function was assessed as the primary endpoint, according to conventional and strain-echocardiography measurements. Also, left atrial (LA) morphofunctional indices were investigated at baseline and at the final visit. Results were expressed as median with interquartile range (IQ). A significant improvement of LV ejection fraction (20.3 (IQ 12.5) vs. −1.67 (IQ 24.8); p = 0.040)), and LA area fractional change (11.1 (IQ 22.6) vs. 2.8 (9.5); p = 0.034)) were observed in genistein patients compared to the controls, following 12 months of treatment. In addition, body surface area indexed LA systolic volume and peak LA longitudinal strain significantly changed from basal to the end of the study in genistein-treated patients. One-year supplementation with 54 mg/day of pure genistein improved both LV ejection fraction and LA remodeling and function in postmenopausal women with MetS.

【 授权许可】

Unknown