Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes

International Journal of Molecular Sciences

Pavel Georgiev¹  Olga Kyrchanova¹ 

[1] Department of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, Russia;

关键词: C2H2 proteins;    CTCF;    LDB1;    chromatin insulator;    long-distance interactions;   

DOI  :  10.3390/ijms22020671

来源: DOAJ

【 摘 要 】

In higher eukaryotes, enhancers determine the activation of developmental gene transcription in specific cell types and stages of embryogenesis. Enhancers transform the signals produced by various transcription factors within a given cell, activating the transcription of the targeted genes. Often, developmental genes can be associated with dozens of enhancers, some of which are located at large distances from the promoters that they regulate. Currently, the mechanisms underlying specific distance interactions between enhancers and promoters remain poorly understood. This review briefly describes the properties of enhancers and discusses the mechanisms of distance interactions and potential proteins involved in this process.

【 授权许可】

Unknown