Clinical and epidemiological characteristics of Korean patients with hepatitis C virus genotype 6

Clinical and Molecular Hepatology

Han Chu Lee¹  Youn Jae Lee²  Sook-Hyang Jeong³  Jin-Wook Kim³  Mun Hyuk Seong³  Jong Yeop Kim³  Ho Kil³  Eun Sun Jang³  Sang Soo Lee³  Young Seok Kim⁴  Si Hyun Bae⁵  Haesun Yun⁶  Kisang Kim⁶  Byung Hak Kang⁶ 

[1] Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.;Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.;Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.;Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.;Department of Internal Medicine, The Catholic University of Korea Seoul Saint Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.;Division of Enteric and Hepatitis Viruses, Korea Centers for Disease Control and Prevention, Osong, Korea.;

关键词: HCV;    Genotype;    Epidemiology;    Treatment;    Korea;   

DOI  :  10.3350/cmh.2013.19.1.45

来源: DOAJ

【 摘 要 】

Background/AimsThe distribution of hepatitis C virus (HCV) genotypes varies geographically. In Korea, genotypes 1 and 2 comprise more than 90% of HCV infections, while genotype 6 is very rare. This study compared the clinical and epidemiological characteristics of patients with genotype 6 HCV infection with those infected with HCV genotypes 1 and 2.MethodsThis was a prospective, multicenter HCV cohort study that enrolled 1,173 adult patients, of which 930 underwent HCV genotype analysis, and only 9 (1.0%) were found to be infected with genotype 6 HCV. The clinical and epidemiological parameters of the genotypes were compared.ResultsThe patients with genotype 6 HCV had a mean age of 41.5 years, 77.8% were male, and they had no distinct laboratory features. A sustained virologic response (SVR) was observed in four (67%) of six patients who received antiviral therapy. Risk factors such as the presence of a tattoo (n=6, 66.7%), more than three sexual partners (n=3, 33.3%), and injection drug use (n=3, 33.3%) were more common among genotype 6 patients than among genotypes 1 or 2.ConclusionsThe epidemiology and treatment response of patients infected with genotype 6 HCV differed significantly from those with genotypes 1 or 2, warranting continuous monitoring.

【 授权许可】

Unknown