2-Phenylacetamide Isolated from the Seeds of Lepidium apetalum and Its Estrogen-Like Effects In Vitro and In Vivo

Molecules

Miao Li¹  Beibei Zhang¹  Weisheng Feng¹  Mengnan Zeng¹  Xiaoke Zheng¹  Meng Li¹  Benke Li¹  Li Zhang¹ 

[1] Department of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China;

关键词: Lepidium apetalum Willd;    2-phenylacetamide;    estrogen-like effects;    ERα;    ERβ;    GPR30;   

DOI  :  10.3390/molecules23092293

来源: DOAJ

【 摘 要 】

The aim of this study was to investigate the estrogen-like effects of 2-phenylacetamide (PA), which is the main compound isolated from the seeds of Lepidium apetalum Willd (LA). Results showed that LA and PA could promote the proliferation of MCF-7 cells. The mouse uterine weight test showed that, LA and PA could increase the uterus index of immature female mice, and the levels of luteinizing hormone (LH) and estrogen (E2). LA could increase the expression of ERα and ERβ, while PA could increase the expression of ERα, ERβ and GPR30 in the uterus and MCF-7 cells. In addition, co-incubation of the estrogen receptor blocker with LA or PA abolished the inductive effect of the proliferation. PA has estrogenic activities and was the material basis of LA that played the estrogenic effect. LA and PA might be used for the treatment of perimenopause syndrome in a novel application.

【 授权许可】

Unknown