Molecules | |
2-Phenylacetamide Isolated from the Seeds of Lepidium apetalum and Its Estrogen-Like Effects In Vitro and In Vivo | |
Miao Li1  Beibei Zhang1  Weisheng Feng1  Mengnan Zeng1  Xiaoke Zheng1  Meng Li1  Benke Li1  Li Zhang1  | |
[1] Department of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China; | |
关键词: Lepidium apetalum Willd; 2-phenylacetamide; estrogen-like effects; ERα; ERβ; GPR30; | |
DOI : 10.3390/molecules23092293 | |
来源: DOAJ |
【 摘 要 】
The aim of this study was to investigate the estrogen-like effects of 2-phenylacetamide (PA), which is the main compound isolated from the seeds of Lepidium apetalum Willd (LA). Results showed that LA and PA could promote the proliferation of MCF-7 cells. The mouse uterine weight test showed that, LA and PA could increase the uterus index of immature female mice, and the levels of luteinizing hormone (LH) and estrogen (E2). LA could increase the expression of ERα and ERβ, while PA could increase the expression of ERα, ERβ and GPR30 in the uterus and MCF-7 cells. In addition, co-incubation of the estrogen receptor blocker with LA or PA abolished the inductive effect of the proliferation. PA has estrogenic activities and was the material basis of LA that played the estrogenic effect. LA and PA might be used for the treatment of perimenopause syndrome in a novel application.
【 授权许可】
Unknown