Digesting the crisis: autophagy and coronaviruses

Microbial Cell

Guido Kroemer¹  Maria A. Bauer²  Didac Carmona-Gutierrez²  Frank Madeo²  Andreas Zimmermann²  Sebastian J. Hofer²  Katharina Kainz² 

[1] Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France.;Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.;

关键词: covid-19;    sars;    sars-cov-2;    mers;    coronavirus;    virophagy;    inflammation;    immunity;   

DOI  :  10.15698/mic2020.05.715

来源: DOAJ

【 摘 要 】

Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the inhibition of excessive inflammatory reactions. In line with its central role in immunity, viruses have evolved mechanisms to interfere with or to evade the autophagic process, and in some cases, even to harness autophagy or constituents of the autophagic machinery for their replication. Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this piece, we provide a short overview of the evidence linking autophagy to coronaviruses and discuss whether such links may provide actionable targets for therapeutic interventions.

【 授权许可】

Unknown