Time-Course of Salivary Metabolomic Profiles during Radiation Therapy for Head and Neck Cancer

Journal of Clinical Medicine

Takao Ueno¹  Wakako Yatsuoka¹  Kanako Miyano²  Yasuhito Uezono²  Ayame Enomoto³  Masahiro Sugimoto³  Sana Ota³ 

[1] Dental Division, National Cancer Center Hospital, Tokyo 104-0045, Japan;Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo 104-0045, Japan;Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan;

关键词: metabolomic analysis;    oral mucositis;    radiation therapy;    capillary electrophoresis-mass spectrometry;    saliva;   

DOI  :  10.3390/jcm10122631

来源: DOAJ

【 摘 要 】

Oral mucositis (OM) is one of the most frequently observed adverse oral events in radiation therapy for patients with head and neck cancer. Thus, objective evaluation of OM severity is needed for early and timely intervention. Here, we analyzed the time-course of salivary metabolomic profiles during the radiation therapy. The severity of OM (National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events v3.0) of nine patients with head and neck cancer was evaluated. Partial least squares regression-discriminant analysis, using samples collected before radiation therapy, showed that histidine and tyrosine highly discriminated high-grade OM from low-grade OM before the start of radiation therapy (significant difference, p = 0.048 for both metabolites). Further, the pretreatment concentrations of gamma-aminobutyric acid and 2-aminobutyric acids were higher in the high-grade OM group. Although further validations are still necessary, this study showed potentially associated metabolites with worse radiotherapy-related OM among patients with head and neck cancer.

【 授权许可】

Unknown