Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum

Natural Products and Bioprospecting

Yu Song¹  Xiao Ding¹  Bao-Jia Yang¹  Wen-Fang Yi¹  Hai-Li Yu¹  Qin Long¹  Shun-Lin Li¹  Xiao-Jiang Hao¹ 

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences;

关键词: Cynanchum paniculatum;    Steroidal glycosides;    Bioactivities;    NMR data;   

DOI  :  10.1007/s13659-019-0205-2

来源: DOAJ

【 摘 要 】

Abstract Two new C21 steroidal glycosides, paniculatumosides H and I, together with four known ones were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were identified by spectroscopic methods including extensive 1D and 2D NMR techniques. All compounds were subjected to detect the anti-tobacco mosaic virus (TMV) activities and their cytotoxities against three human tumor cell lines (SMMC-7721, MDA-MB-231 and A549). The results showed that compounds 1 and 5 exhibited potent protective activities against TMV, while 2, 4 and 6 had moderate effects on the SMMC-7721 cancer cells viability. Graphical Abstract

【 授权许可】

Unknown