Sexual Dimorphism of Corticosteroid Signaling during Kidney Development

International Journal of Molecular Sciences

Say Viengchareun¹  Margaux Laulhé¹  Laurence Dumeige¹  ThiAn Vu¹  Imene Hani¹  Eric Pussard¹  Laetitia Martinerie¹  Marc Lombès¹ 

[1] Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, CEDEX, 94276 Le Kremlin-Bicêtre, France;

关键词: aldosterone;    cortisol;    mineralocorticoid and glucocorticoid receptors;    neonates;    kidney;    development;   

DOI  :  10.3390/ijms22105275

来源: DOAJ

【 摘 要 】

Sexual dimorphism involves differences between biological sexes that go beyond sexual characteristics. In mammals, differences between sexes have been demonstrated regarding various biological processes, including blood pressure and predisposition to develop hypertension early in adulthood, which may rely on early events during development and in the neonatal period. Recent studies suggest that corticosteroid signaling pathways (comprising glucocorticoid and mineralocorticoid signaling pathways) have distinct tissue-specific expression and regulation during this specific temporal window in a sex-dependent manner, most notably in the kidney. This review outlines the evidence for a gender differential expression and activation of renal corticosteroid signaling pathways in the mammalian fetus and neonate, from mouse to human, that may favor mineralocorticoid signaling in females and glucocorticoid signaling in males. Determining the effects of such differences may shed light on short term and long term pathophysiological consequences, markedly for males.

【 授权许可】

Unknown