Calcium and Spike Timing-Dependent Plasticity

Frontiers in Cellular Neuroscience

Yanis Inglebert¹  Dominique Debanne² 

[1] Department of Pharmacology and Therapeutics and Cell Information Systems, McGill University, Montreal, QC, Canada;UNIS, UMR1072, INSERM, Aix-Marseille University, Marseille, France;

关键词: synaptic plasticity;    synapse;    STDP;    hippocampus;    learning;    memory;   

DOI  :  10.3389/fncel.2021.727336

来源: DOAJ

【 摘 要 】

Since its discovery, spike timing-dependent synaptic plasticity (STDP) has been thought to be a primary mechanism underlying the brain’s ability to learn and to form new memories. However, despite the enormous interest in both the experimental and theoretical neuroscience communities in activity-dependent plasticity, it is still unclear whether plasticity rules inferred from in vitro experiments apply to in vivo conditions. Among the multiple reasons why plasticity rules in vivo might differ significantly from in vitro studies is that extracellular calcium concentration use in most studies is higher than concentrations estimated in vivo. STDP, like many forms of long-term synaptic plasticity, strongly depends on intracellular calcium influx for its induction. Here, we discuss the importance of considering physiological levels of extracellular calcium concentration to study functional plasticity.

【 授权许可】

Unknown