BLOOD PRESSURE VARIABILITY AND ARTERIAL STIFFNESS

Artery Research

关键词: Arterial stiffness;    Blood pressure variability;    Wave reflections;   

DOI  :  10.1016/j.artres.2011.10.001

来源: DOAJ

【 摘 要 】

Blood pressure variability (BPV) is defined by the standard deviation of a given sample of population of normotensive or hypertensive subjects. Recent studies have suggested that this parameter might constitute a cardiovascular risk factor. Reduction of blood pressure variability could be an important purpose of anti-hypertensive treatment, as suggested from experimental studies. In a double-blind controlled investigation, the thiazide compound indapamide was compared to placebo, to the angiotensin blocker candesartan and to the calcium-entry blocker amlodipine for 12 weeks treatment. The 3 drugs reduced significantly and identically blood pressure. Only indapamide and amlodipine reduced significantly BPV. This study was the first to demonstrate the interest of BPV in the setting of a double-blind, placebo controlled, trial.

【 授权许可】

Unknown