Banana starch intervention ameliorates diabetes-induced mood disorders via modulation of the gut microbiota-brain axis in diabetic rats

Food and Agricultural Immunology

Weidong Bai¹  Jingwen Guo²  Zhenshan Peng²  Roumin Lin²  Junming Lin²  Yongliang Bai²  Meiguo Xin²  Jing Xie² 

[1] College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, People’s Republic of China;School of Food Science and Engineering, Foshan University, Foshan, People’s Republic of China;

关键词: Diabetes;    resistant starch;    banana;    mood disorders;    gut-microbiota-brain axis;   

DOI  :  10.1080/09540105.2022.2071846

来源: DOAJ

【 摘 要 】

Bananas (Musa spp.) enriched in resistant starch displayed multiple health benefits for diabetes. Here, we showed that banana starch administered to diabetic rats improved animal depressive-like behaviours of mood disorders. Four weeks of banana starch diet to high-sugar, high-fat, and STZ-induced diabetic rats lowered their blood insulin resistance, but increased their plasma HDL cholesterol and 5-HT levels, compared to the control groups of rats. The banana starch diet reconstructed the gut microbiota and increased their metabolite of butyrate, as well as increased the activity of superoxidase in diabetic rats. Furthermore, Banana starch intervention significantly increased the exhaustion time of the diabetic rats, and almost restored it to the normal state of control groups in their swimming and tail suspension tests. Together, our results indicated the modulation of the gut-microbiota-brain axis as a possible mechanism that enables the banana starch diet as a potential therapeutic way for diabetes-associated mood disorders.

【 授权许可】

Unknown