Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study

Journal of Health, Population and Nutrition

Edith Pascale M. Mato¹  Aurelie Nguimmo-Metsadjio¹  Barbara Atogho-Tiedeu¹  Olivier Sontsa Donfack¹  Marie-Solange Evehe¹  Rosine Djokam-Dadjeu¹  Elvis Ndonwi Ngwa¹  Priscille Pokam-Fosso¹  Wilfred F. Mbacham¹  Dieudonne Nanfa¹  Magellan Guewo-Fokeng¹  Jean Jacques Noubiap²  Eugene Sobngwi³  Jean Claude Mbanya³ 

[1] Department of Biochemistry, Faculty of Science, University of Yaoundé I;Department of Medicine, Groote Schuur Hospital and University of Cape Town;Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I;

关键词: Obesity;    Genetic association;    TCF7L2;    rs7903146 (C/T) polymorphism;    Sub-Saharan Africa;    Cameroon;   

DOI  :  10.1186/s41043-017-0087-z

来源: DOAJ

【 摘 要 】

Abstract Objective This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. Method This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters. Results The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups. Conclusion The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.

【 授权许可】

Unknown