Feasibility of a Combined Mobile-Health Electrocardiographic and Rapid Diagnostic Test Screening for Chagas-Related Cardiac Alterations

Microorganisms

Niccolò Maurizi¹  Mimmo Roselli²  Iacopo Olivotto²  Enrico Guglielmi²  Alessandro Bartoloni²  Michele Spinicci²  Carlo Fumagalli²  Marianne Strohmeyer²  Veronica Poma³  Herlan Gamboa⁴  Roberto Vargas⁵ 

[1] Cardiomyopathy Unit, Cardiothoracic and Vascular Department, Careggi University Hospital, 50134 Florence, Italy;Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy;Escuela de Salud del Chaco Tekove Katu, Gutierrez, Bolivia;Facultad Integral del Chaco, Universidad Autónoma Gabriel René Moreno, Camiri, Bolivia;Programa Nacional de Chagas, Ministerio de Salud, La Paz, Bolivia;

关键词: Chagas disease;    Chagas Stat-Pak;    chronic Chagas cardiomyopathy;    mHealth;    telemedicine;    seroprevalence;   

DOI  :  10.3390/microorganisms9091889

来源: DOAJ

【 摘 要 】

Background: Chronic Chagas cardiomyopathy (CChC) is the most common cause of death related to Chagas disease (CD). The aim of this study was to assess the feasibility of a combined rapid diagnostic test (RDT) and electrocardiographic (ECG) screening in a remote rural village of the Bolivian Chaco, with a high prevalence of CChC. Methods: Consecutive healthy volunteers > 15 years were enrolled in the community of Palmarito (municipality of Gutierrez, Santa Cruz Department, Bolivia) in February 2019. All patients performed an RDT with Chagas Stat-Pak^® (CSP, Chembio Diagnostic System, Medford, NY, USA) and an ECG by D-Heart^® technology, a low-cost, user-friendly smartphone-based 8-lead Bluetooth ECG. RDTs were read locally while ECGs were sent to a cardiology clinic which transmitted reports within 24 h from recording. Results: Among 140 people (54 men, median age 38(interquartile range 23–54) years), 98 (70%) were positive for Trypanosoma cruzi infection, with a linear, age-dependent, increasing trend (p < 0.001). Twenty-five (18%) individuals showed ECG abnormalities compatible with CD. Prevalence of ECG abnormalities was higher in infected individuals and was associated with higher systolic blood pressure and smoking. Following screening, 22 (16%) individuals underwent clinical evaluation and chest X-ray and two were referred for further evaluation. At multivariate analysis, positive CSP results (OR = 4.75, 95%CI 1.08–20.96, p = 0.039) and smoking (OR = 4.20, 95%CI 1.18–14.92, p = 0.027) were independent predictors of ECG abnormalities. Overall cost for screening implementation was <10 $. Conclusions: Combined mobile-Health and RDTs was a reliable and effective low-cost strategy to identify patients at high risk of disease needing cardiologic assessment suggesting potential future applications.

【 授权许可】

Unknown