Strategies for Cancer Treatment Based on Photonic Nanomedicine

Materials

Roger Borges¹  AnaCarolina Santos de Souza¹  AmedeaB. Seabra¹  Juliana Marchi¹  Derval dos Santos Rosa²  Sueli Aparecida de Oliveira²  Francesco Baino³ 

[1] Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados, 5001 Santa Terezinha, Santo André 09210580, Brazil;Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas, Universidade Federal do ABC, Avenida dos Estados, 5001 Santa Terezinha, Santo André 09210580, Brazil;Department of Applied Science and Technology, Institute of Materials Physics and Engineering, Politecnico di Torino, Corso Duca degli Abruzzi, 10129 Torino, Italy;

关键词: nanomedicine;    photonic;    cancer treatment;    photothermal therapy;    photodynamic therapy;    drug delivery systems;   

DOI  :  10.3390/ma14061435

来源: DOAJ

【 摘 要 】

Traditional cancer treatments, such as surgery, radiotherapy, and chemotherapy, are still the most effective clinical practice options. However, these treatments may display moderate to severe side effects caused by their low temporal or spatial resolution. In this sense, photonic nanomedicine therapies have been arising as an alternative to traditional cancer treatments since they display more control of temporal and spatial resolution, thereby yielding fewer side effects. In this work, we reviewed the challenge of current cancer treatments, using the PubMed and Web of Science database, focusing on the advances of three prominent therapies approached by photonic nanomedicine: (i) photothermal therapy; (ii) photodynamic therapy; (iii) photoresponsive drug delivery systems. These photonic nanomedicines act on the cancer cells through different mechanisms, such as hyperthermic effect and delivery of chemotherapeutics and species that cause oxidative stress. Furthermore, we covered the recent advances in materials science applied in photonic nanomedicine, highlighting the main classes of materials used in each therapy, their applications in the context of cancer treatment, as well as their advantages, limitations, and future perspectives. Finally, although some photonic nanomedicines are undergoing clinical trials, their effectiveness in cancer treatment have already been highlighted by pre-clinical studies.

【 授权许可】

Unknown