期刊论文详细信息
Open Biology
Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease
Sandeep Kumar Singh1  Vyshnavy Balendra2 
[1] Indian Scientific Education and Technology (ISET) Foundation, Lucknow 226002, India;Saint James School of Medicine, Park Ridge, IL, 60068, USA;
关键词: oxidative stress;    nutraceuticals;    astaxanthin;    superoxide dismutase (SOD);    neurodegeneration;    Alzheimer's disease;   
DOI  :  10.1098/rsob.210013
来源: DOAJ
【 摘 要 】

Oxidative stress, the imbalance of the antioxidant system, results in an accumulation of neurotoxic proteins in Alzheimer's disease (AD). The antioxidant system is composed of exogenous and endogenous antioxidants to maintain homeostasis. Superoxide dismutase (SOD) is an endogenous enzymatic antioxidant that converts superoxide ions to hydrogen peroxide in cells. SOD supplementation in mice prevented cognitive decline in stress-induced cells by reducing lipid peroxidation and maintaining neurogenesis in the hippocampus. Furthermore, SOD decreased expression of BACE1 while reducing plaque burden in the brain. Additionally, Astaxanthin (AST), a potent exogenous carotenoid, scavenges superoxide anion radicals. Mice treated with AST showed slower memory decline and decreased depositions of amyloid-beta (Aβ) and tau protein. Currently, the neuroprotective potential of these supplements has only been examined separately in studies. However, a single antioxidant cannot sufficiently resist oxidative damage to the brain, therefore, a combinatory approach is proposed as a relevant therapy for ameliorating pathological changes in AD.

【 授权许可】

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