Recent Advances in Small Peptides of Marine Origin in Cancer Therapy

Marine Drugs

Tao Wang¹  Yu-Fen Zhao¹  Qi-Ting Zhang¹  Ning Wang¹  Ze Wang²  Ze-Dong Liu²  Bin Zhang²  Nan Wang³ 

[1] Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China;Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China;Quality Assurance Department, Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518057, China;

关键词: marine organism;    anticancer medicine;    small peptide;    liner peptide;    cyclic peptide;   

DOI  :  10.3390/md19020115

来源: DOAJ

【 摘 要 】

Cancer is one of the leading causes of death in the world, and antineoplastic drug research continues to be a major field in medicine development. The marine milieu has thousands of biological species that are a valuable source of novel functional proteins and peptides, which have been used in the treatment of many diseases, including cancer. In contrast with proteins and polypeptides, small peptides (with a molecular weight of less than 1000 Da) have overwhelming advantages, such as preferential and fast absorption, which can decrease the burden on human gastrointestinal function. Besides, these peptides are only connected by a few peptide bonds, and their small molecular weight makes it easy to modify and synthesize them. Specifically, small peptides can deliver nutrients and drugs to cells and tissues in the body. These characteristics make them stand out in relation to targeted drug therapy. Nowadays, the anticancer mechanisms of the small marine peptides are still largely not well understood; however, several marine peptides have been applied in preclinical treatment. This paper highlights the anticancer linear and cyclic small peptides in marine resources and presents a review of peptides and the derivatives and their mechanisms.

【 授权许可】

Unknown