Prenatal Exposure to BPA: The Effects on Hepatic Lipid Metabolism in Male and Female Rat Fetuses

Nutrients

Maurizio Mandal๠ Laura Barberio¹  Arianna Mazzoli²  Luisa Cigliano²  Marco Segatto³  Valentina Pallottini⁴  Claudia Tonini⁴  Simona Bertoli⁵  Alessandro Leone⁵ 

[1] Department of Biology, Ecology and Earth Science, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy;Department of Biology, University of Naples Federico II, Complesso Universitario Monte Sant’Angelo, Via Cinthia—Edificio 7, 80126 Naples, Italy;Department of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche, Italy;Department of Science, University Roma Tre, Viale Marconi 446, 00146 Rome, Italy;International Center for the Assessment of Nutritional Status (ICANS), Department of Food Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy;

关键词: acyl coenzyme A carboxylase;    bisphenol A;    cholesterol;    fatty acids;    3-hydroxy 3-methylglutaryl coenzyme A reductase;    fetuses;   

DOI  :  10.3390/nu13061970

来源: DOAJ

【 摘 要 】

Bisphenol A (BPA) is an organic chemical compound widely used for manufacturing plastics. BPA exposure originates principally from the diet, but it can also originate from dermal contact. In over 90% of individuals, including pregnant women, BPA is detectable in several body fluids. The effects of this exposure on the fetus are under active investigation in several research laboratories. The aim of our work was to study the impact of prenatal exposure to BPA in the liver of rat fetuses from a sex-dependent point of view. We particularly investigated the effects of prenatal BPA exposure on hepatic lipids because of their crucial role, not only for the liver, but also for the whole-body functions. Our results demonstrate that the liver of rat fetuses, in utero exposed to a very low dose of BPA (2.5 µg/kg/day), displays significant modulations with regard to proteins involved in cholesterol and fatty acid biosynthesis and trafficking. Moreover, an impact on inflammatory process has been observed. All these effects are dependent on sex, being observable only in female rat fetuses. In conclusion, this work demonstrates that maternal exposure to BPA compromises hepatic lipid metabolism in female offspring, and it also reveals the perspective impact of BPA on human health at doses currently considered safe.

【 授权许可】

Unknown