Relationship of Excess Weight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients

Nutrients

Barbara Vizmanos-Lamotte¹  Marta Garaulet²  Isela Parra-Rojas³  Erika Martínez-López⁴  Ulises De la Cruz-Mosso⁴  Edith Oregon-Romero⁴  MónicaR. Meza-Meza⁴  JoséFrancisco Muñoz-Valle⁴  Bertha Campos-López⁴  Margarita Montoya-Buelna⁵  Sergio Cerpa-Cruz⁶ 

[1] Cuerpo Académico (CA) 454 “Alimentación y Nutrición en el Proceso Salud-Enfermedad” Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco 44340, Mexico;Department of Physiology/Research Biomedical Institute of Murcia (IMIB)-Arrixaca, University of Murcia, Murcia 30120, Spain;Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo de los Bravo, Guerrero 39087, Mexico;Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco 44340, Mexico;Laboratorio de Inmunología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara. Sierra Mojada 950, Guadalajara, Jalisco 44340, Mexico;Servicio de Reumatología, O.P.D. Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco 44280, Mexico;

关键词: nutritional status;    dietary status;    systemic lupus erythematosus;    excess weight;    clinical activity;    obesity;    nutrients;    deficiencies;    immunomodulation;   

DOI  :  10.3390/nu11112683

来源: DOAJ

【 摘 要 】

Obesity and nutrients intake deficiencies may contribute to the clinical manifestations and inflammatory processes in systemic lupus erythematosus (SLE). The aim of this study was to assess the relationship between nutritional status and dietary intake with clinical variables in Mexican-mestizo SLE patients. A cross-sectional study was conducted in 130 female SLE patients, classified by the 1997 SLE American College of Rheumatology (ACR) criteria; the clinical activity was evaluated by the Mexican-Systemic Lupus Erythematosus-Disease Activity Index (Mex-SLEDAI); body mass index (BMI) by the World Health Organization (WHO) criteria; the energy calculation and nutritional intake were performed by Nutritionist Pro Diet software. SLE patients with excess weight (BMI > 25 kg/m²) showed a higher score of clinical activity (Mex-SLEDAI = 2; p = 0.003), higher clinical activity prevalence (40.9%; p = 0.039) and a significant association for high clinical activity (odds ratio (OR) = 2.52; 95% confidence interval (CI) = 1.08−5.9; p = 0.033), in comparison with patients without excess weight (BMI < 25 kg/m²). In particular, the excess weight increased the Mex-SLEDAI score (β coefficient = 1.82; R² = 0.05; p = 0.005). Also, the SLE patients presented a high prevalence (%) of deficient consumption (cut-off point: <67% of dietary adequacy) of vitamin E (100%), iodine (96%), omega 3 (93.44%), biotin (78%), vitamin K (73.33%), iron (67%), vitamin D (63.3%), potassium (59%), folic acid (56.67%), pantothenic acid (43.3%), vitamin A (41.67%) and zinc (32%). In conclusion, in SLE patients the excess weight was associated with increased clinical activity and to the presence of deficiencies in some essential nutrients ingested.

【 授权许可】

Unknown