Biocompatibility of biphasic α,β-tricalcium phosphate ceramics in vitro

Bioactive Materials

I.I. Selezneva¹  S.A. Tikhonova²  T.B. Shatalova²  G.A. Davydova³  D.S. Larionov³  T.V. Safronova³  A.S. Kiselev³  J.V. Rau³ 

[1] Corresponding author.;Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142292, Moscow Region, Russia;Lomonosov Moscow State University, Leninskie Gory, 1, Moscow, 119991, Russia;

关键词: Tricalcium phosphate;    Ceramics;    Phase composition;    Dental pulp stem cells;    Biocompatibility;   

DOI  :  

来源: DOAJ

【 摘 要 】

The biocompatibility of biphasic α,β-tricalcium phosphate ceramics, obtained by annealing a compact preform based on β-tricalcium phosphate powder, was studied in vitro. It was found that within 10–30 days the adhesion of primary dental pulp stem cells located on the surface of biphasic α,β-tricalcium phosphate ceramics is suppressed. Decrease of the cell number on the surface of biphasic α,β-tricalcium phosphate ceramics, most likely, can be associated with both the pH level (acidic) as a result of hydrolysis of the more soluble phase of α-tricalcium phosphate and with the nature of surface that changes as a result of the formation and growth of hydroxyapatite crystals.

【 授权许可】

Unknown