Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation

Molecules

Ciriana Orabona¹  Elena Orecchini¹  Claudio Baiocchi²  Cinzia Pagano³  Michela Chielli³  Maurizio Ricci³  Luana Perioli³  Tommaso Beccari³  Maura Marinozzi³  Paola Calarco³  MariaRachele Ceccarini³  MariaCristina Tiralti³  Stefania Scuota⁴  Roberta Ortenzi⁴ 

[1] Department of Experimental Medicine, Sect. Pharmacology, University of Perugia, P.le L. Severi 1, Bld C/4th floor, 06132 Perugia, Italy;Department of Molecular Biotechnology and Health Sciences, Sect. Analytical Chemistry, Via Pietro Giuria 5, 10125 Torino, Italy;Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, Italy;Istituto Zooprofilattico dell’Umbria e delle Marche, via G. Salvemini, 1, 06126 Perugia, Italy;

关键词: onion skins extract;    hydrogel;    polymeric films;    anti-inflammatory;    antibacterial;   

DOI  :  10.3390/molecules25020318

来源: DOAJ

【 摘 要 】

The onion non-edible outside layers represent a widely available waste material deriving from its processing and consumption. As onion is a vegetable showing many beneficial properties for human health, a study aiming to evaluate the use of extract deriving from the non-edible outside layers was planned. An eco-friendly extraction method was optimized using a hydroalcoholic solution as solvent. The obtained extract was deeply characterized by in vitro methods and then formulated in autoadhesive, biocompatible and pain-free hydrogel polymeric films. The extract, very soluble in water, showed antioxidant, radical scavenging, antibacterial and anti-inflammatory activities, suggesting a potential dermal application for wounds treatment. In vitro studies showed a sustained release of the extract from the hydrogel polymeric film suitable to reach concentrations necessary for both antibacterial and anti-inflammatory activities. Test performed on human keratinocytes showed that the formulation is safe suggesting that the projected formulation could be a valuable tool for wound treatment.

【 授权许可】

Unknown