Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis

Frontiers in Physiology

Bin Liu¹  Luya Pu²  Xizi Luo²  Baisen Wang²  Qingyu Meng²  Fan Li⁵ 

[1] Cardiovascular Disease Center, The First Hospital of Jilin University, Changchun, China;Department of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University, Changchun, China;Engineering Research Center for Medical Biomaterials of Jilin Province, Jilin University, Changchun, China;Key Laboratory for Health Biomedical Materials of Jilin Province, Jilin University, Changchun, China;State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang, China;The Key Laboratory for Bionics Engineering, Ministry of Education, Jilin University, Changchun, China;

关键词: lncRNA;    atherosclerosis;    vascular cells;    lipid metabolism;    inflammatory response;    angiogenesis;   

DOI  :  10.3389/fphys.2020.564604

来源: DOAJ

【 摘 要 】

Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease, which comprise serious hazards to human health. Atherosclerosis is characterized by the deposition of lipids on the interior walls of blood vessels, causing an inflammatory response of immune cells, endothelial cells, and smooth muscle cells, and a proliferation cascade reaction. Despite years of research, the underlying pathogenesis of AS is not fully defined. Recent advances in our understanding of the molecular mechanisms by which non-coding RNA influences the initiation and progression of AS have shown that long non-coding RNAs (lncRNAs) regulate important stages in the atherosclerotic process. In this review, we summarize current knowledge of lncRNAs, which influence the development of AS. We review the regulatory processes of lncRNAs on core stages of atherosclerotic progression, including lipid metabolism, inflammation, vascular cell proliferation, apoptosis, adhesion and migration, and angiogenesis. A growing body of evidence suggests that lncRNAs have great potential as new therapeutic targets for the treatment of vascular diseases.

【 授权许可】

Unknown