Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients

BMC Cancer

Satoru Takahashi¹  Yoichi Matsuo²  Ken Tsuboi²  Toyonori Omori³  Jiegou Xu⁴  Mouka Tamura⁵  Takeshi Tokuyama⁶  Yoshifumi Yokoyama⁷  Takeshi Ebara⁸  Tetsuya Oguri⁹  Akio Niimi⁹  Masayuki Nishio^1,10  Kosho Yoshikawa^1,10  Munehiro Kato^1,11  Ikuji Usami^1,11  Takako Yokoyama^1,11  Nobukazu Fujimoto^1,12  Takumi Kishimoto^1,12  William T. Alexander^1,13  David B. Alexander^1,13  Hiroyuki Tsuda^1,13  Mohamed Abdelgied^1,13 

[1] Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences;Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences;Department of Healthcare Policy and Management, Nagoya City University Graduate School of Medical Sciences;Department of Immunology, College of Basic Medical Sciences, Anhui Medical University;Department of Internal Medicine, National Hospital Organization Nara Medical Center;Department of Internal Medicine, Saiseikai Chuwa Hospital;Department of Medicine and Physical Medicine and Rehabilitation, Nagoya City Koseiin Medical Welfare Center;Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences;Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences;Department of Respiratory Medicine, Daido Hospital;Japan Organization of Occupational Health and Safety, Department of Respiratory Medicine, Asahi Rosai Hospital;Japan Organization of Occupational Health and Safety, Research Center for Asbestos-related Diseases, Okayama Rosai Hospital;Nanotoxicology Project Lab, Nagoya City University;

关键词: Asbestos;    Cancer;    Malignant pleural mesothelioma;    CCL2;   

DOI  :  10.1186/s12885-019-6419-1

来源: DOAJ

【 摘 要 】

Abstract Background Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammatory response. Repeated exposure to asbestos fibers results in a prolonged inflammatory response and cycles of tissue damage and repair. The inflammation-associated cycles of tissue damage and repair are intimately involved in the development of asbestos-associated cancers. Macrophages are a key component of asbestos-associated inflammation and play essential roles in the etiology of a variety of cancers. Macrophages are also a source of C-C motif chemokine ligand 2 (CCL2), and a variety of tumor-types express CCL2. High levels of CCL2 are present in the pleural effusions of mesothelioma patients, however, CCL2 has not been examined in the serum of mesothelioma patients. Methods The present study was carried out with 50 MPM patients and 356 subjects who were possibly exposed to asbestos but did not have disease symptoms and 41 healthy volunteers without a history of exposure to asbestos. The levels of CCL2 in the serum of the study participants was determined using ELISA. Results Levels of CCL2 were significantly elevated in the serum of patients with advanced MPM. Conclusions Our findings are consistent with the premise that the CCL2/CCR2 axis and myeloid-derived cells play an important role in MPM and disease progression. Therapies are being developed that target CCL2/CCR2 and tumor resident myeloid cells, and clinical trials are being pursued that use these therapies as part of the treatment regimen. The results of trials with patients with a similar serum CCL2 pattern as MPM patients will have important implications for the treatment of MPM.

【 授权许可】

Unknown