Comparing the effects of vaginal misoprostol, laminaria, and extra amniotic saline infusion on cervical ripening and induction of labor

Obstetrics & Gynecology Science

Elaheh Mesdaghinia¹  Aida Panahandeh¹  Zohreh Tabasi¹  Masoumeh Abedzadeh-Kalahroudi²  Mojtaba Sehat³ 

[1] Department of Obstetrics and Gynecology, Kashan University of Medical Sciences, Kashan, .Iran;Trauma Nursing Research Center, Kashan University of Medical Sciences, Kashan, .Iran;Trauma Research Center, Kashan University of Medical Sciences, Kashan, .Iran;

关键词: misoprostol;    cervical ripening;    laminaria;    labor;   

DOI  :  10.5468/ogs.2020.63.3.261

来源: DOAJ

【 摘 要 】

ObjectiveThis study aimed to compare the effects of vaginal misoprostol, laminaria, and extra-amniotic saline infusion (EASI) on cervical ripening.MethodsThis randomized controlled trial was conducted on 195 women with singleton pregnancies and unripe cervices. Participants were randomly allocated to 3, 65-person groups: a misoprostol, a laminaria, and an EASI group. The interventions in the misoprostol, laminaria, and EASI groups included a single 25-µg vaginal misoprostol suppository, an intracervical laminaria, and a transcervical Foley catheter, respectively. The groups were compared with each other regarding time intervals from labor induction to labor active phase and delivery, cervical dilation, Bishop scores 6 hours after induction, delivery type, length of hospital stay, and complications.ResultsThere were no significant differences among the groups regarding maternal ages, gestational ages, body mass indices, baseline cervical dilations, and Bishop scores (P>0.05). Six hours after induction, the Bishop score and cervical dilation were significantly greater in the EASI group than in the other 2 groups (P<0.001). Moreover, time intervals from labor induction to labor active phase and delivery in the EASI group were significantly short (P<0.001). The rates of cesarean section, fetal distress, placental abruption, and meconium staining in the misoprostol group were significantly high (P<0.05), and the length of hospital stay in the EASI group was significantly short (P<0.001).ConclusionEASI is a safer and more effective method for cervical ripening. Considering its inexpensiveness, easy accessibility, and greater effectiveness, EASI is recommended for cervical ripening.Trial RegistrationIranian Center for Clinical Trials Identifier: IRCT20170513033941N39

【 授权许可】

Unknown