COMPARISON OF ENALAPRIL AND PERINDOPRIL IN PATIENTS WITH ARTERIAL HYPERTENSION AND LEFT VENTRICLE SYSTOLIC DYSFUNCTION

Racionalʹnaâ Farmakoterapiâ v Kardiologii

O. L. Barbarash¹  A. E. Popelysheva²  N. B. Osetrova²  Yu. I. Grinshtein²  V. V. Shabalin²  D. A. Yakhontov³ 

[1] Kemerovo State Medical Academy;Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky;Novosibirsk State Medical University;

关键词: arterial hypertension;    left ventricle systolic dysfunction;    enalapril;    perindopril;    ambulatory blood pressure monitoring;   

DOI  :  10.20996/1819-6446-2010-6-2-179-184

来源: DOAJ

【 摘 要 】

Aim. To compare efficacy of enalapril and perindopril in patients with arterial hypertension (HT) and left ventricle systolic dysfunction.Material and methods. Patients (n=51) with HT and left ventricle systolic dysfunction (ejection fraction<45%) were included in the prospective open randomized comparative study. Patients were randomized into 2 groups of therapy with enalapril 10-20 mg BID (n=25) or with perindopril 4-8 mg OD (n=26). Hydrochlorothiazide (12,5-25 mg OD) was added in case of ineffective therapy. Routine clinical examination, ambulatory blood pressure (BP) monitoring, an electrocardiogram, an echocardiography were performed in all patients.Results. The 24-hour and night antihypertensive effect of enalapril was more prominent than this of perindopril. Target BP level was reached in 21 patients (84%) of enalapril group and in 20 patients (76,9%) of perindopril group. 8 (30,8%) patients of perindopril group did not reach night target BP level vs 3 (12%) patients of enalapril group. Similar improvement of the left ventricle systolic function was observed in both groups.Conclusion. Enalapril and perindopril demonstrated comparable antihypertensive and cardioprotective effect.

【 授权许可】

Unknown